IT1199374B - Processo per la preparazione di pirido-imidazo-rifamicine - Google Patents

Processo per la preparazione di pirido-imidazo-rifamicine

Info

Publication number
IT1199374B
IT1199374B IT03463/84A IT346384A IT1199374B IT 1199374 B IT1199374 B IT 1199374B IT 03463/84 A IT03463/84 A IT 03463/84A IT 346384 A IT346384 A IT 346384A IT 1199374 B IT1199374 B IT 1199374B
Authority
IT
Italy
Prior art keywords
rifamicine
pirido
imidazo
preparation
Prior art date
Application number
IT03463/84A
Other languages
English (en)
Italian (it)
Other versions
IT8403463A0 (it
Inventor
Cannata Vincenzo
Franco Tomagnone G
Piani Silvano
Marchi Egidio
Original Assignee
Alfa Farmaceutici Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Farmaceutici Spa filed Critical Alfa Farmaceutici Spa
Publication of IT8403463A0 publication Critical patent/IT8403463A0/it
Priority to IT03463/84A priority Critical patent/IT1199374B/it
Priority to EP85104790A priority patent/EP0161534B1/en
Priority to ZA852971A priority patent/ZA852971B/xx
Priority to DE8585104790T priority patent/DE3573120D1/de
Priority to AT85104790T priority patent/ATE46512T1/de
Priority to PH32186A priority patent/PH22007A/en
Priority to US06/727,521 priority patent/US4557866A/en
Priority to CA000480321A priority patent/CA1215708A/en
Priority to PT80446A priority patent/PT80446B/pt
Priority to GR851144A priority patent/GR851144B/el
Priority to ES543115A priority patent/ES543115A0/es
Priority to DK214685A priority patent/DK162647C/da
Priority to IE119185A priority patent/IE58392B1/en
Priority to NO851921A priority patent/NO164242C/no
Priority to JP60102528A priority patent/JPS60252483A/ja
Priority to FI851907A priority patent/FI81101C/fi
Priority to AR85300385A priority patent/AR241913A1/es
Priority to AU42515/85A priority patent/AU568934B2/en
Application granted granted Critical
Publication of IT1199374B publication Critical patent/IT1199374B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT03463/84A 1984-05-15 1984-05-15 Processo per la preparazione di pirido-imidazo-rifamicine IT1199374B (it)

Priority Applications (18)

Application Number Priority Date Filing Date Title
IT03463/84A IT1199374B (it) 1984-05-15 1984-05-15 Processo per la preparazione di pirido-imidazo-rifamicine
EP85104790A EP0161534B1 (en) 1984-05-15 1985-04-19 New process for the synthesis of pyrido-imidazo-refamycins
ZA852971A ZA852971B (en) 1984-05-15 1985-04-19 New process for the synthesis of pyrido-imidazo rifamycins
DE8585104790T DE3573120D1 (en) 1984-05-15 1985-04-19 New process for the synthesis of pyrido-imidazo-refamycins
AT85104790T ATE46512T1 (de) 1984-05-15 1985-04-19 Verfahren zur synthese von pyridoimidazorifamycin.
PH32186A PH22007A (en) 1984-05-15 1985-04-25 A new process for the synthesis of pyridoimidazorifaycins
US06/727,521 US4557866A (en) 1984-05-15 1985-04-26 Process for the synthesis of pyrido-imidazo rifamycins
CA000480321A CA1215708A (en) 1984-05-15 1985-04-29 New process for the synthesis of pyrido-imidazo- rifamycins
PT80446A PT80446B (pt) 1984-05-15 1985-05-13 Novo processo para a sintese de pirido-imidazo-rifamicinas
GR851144A GR851144B (en]) 1984-05-15 1985-05-13
ES543115A ES543115A0 (es) 1984-05-15 1985-05-14 Un nuevo procedimiento para la preparacion de pirido-imidazorifamicinas
DK214685A DK162647C (da) 1984-05-15 1985-05-14 Fremgangsmaade til fremstilling af pyrido-imidazorifamyciner
IE119185A IE58392B1 (en) 1984-05-15 1985-05-14 A new process for the synthesis of pyrido-imidazo-rifamycins
NO851921A NO164242C (no) 1984-05-15 1985-05-14 Fremgangsmaate for fremstilling av pyrido-imidazo-rifamycin-derivater.
JP60102528A JPS60252483A (ja) 1984-05-15 1985-05-14 ピリド‐イミダゾリフアマイシンの新規製造法
FI851907A FI81101C (fi) 1984-05-15 1985-05-14 Nytt foerfarande foer syntetisering av pyridoimidazorifamyciner.
AR85300385A AR241913A1 (es) 1984-05-15 1985-05-15 Un nuevo procedimiento para la preparacion de rifamicinas pirido-imidazo.
AU42515/85A AU568934B2 (en) 1984-05-15 1985-05-15 New process for the synthesis of pyrido-imidazo-rifamycins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT03463/84A IT1199374B (it) 1984-05-15 1984-05-15 Processo per la preparazione di pirido-imidazo-rifamicine

Publications (2)

Publication Number Publication Date
IT8403463A0 IT8403463A0 (it) 1984-05-15
IT1199374B true IT1199374B (it) 1988-12-30

Family

ID=11107845

Family Applications (1)

Application Number Title Priority Date Filing Date
IT03463/84A IT1199374B (it) 1984-05-15 1984-05-15 Processo per la preparazione di pirido-imidazo-rifamicine

Country Status (18)

Country Link
US (1) US4557866A (en])
EP (1) EP0161534B1 (en])
JP (1) JPS60252483A (en])
AR (1) AR241913A1 (en])
AT (1) ATE46512T1 (en])
AU (1) AU568934B2 (en])
CA (1) CA1215708A (en])
DE (1) DE3573120D1 (en])
DK (1) DK162647C (en])
ES (1) ES543115A0 (en])
FI (1) FI81101C (en])
GR (1) GR851144B (en])
IE (1) IE58392B1 (en])
IT (1) IT1199374B (en])
NO (1) NO164242C (en])
PH (1) PH22007A (en])
PT (1) PT80446B (en])
ZA (1) ZA852971B (en])

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6861053B1 (en) 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US7048906B2 (en) 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US7078399B2 (en) * 2001-12-13 2006-07-18 Activbiotics, Inc. Sulfhydryl rifamycins and uses thereof
US7923553B2 (en) 2003-11-07 2011-04-12 Alfa Wassermann, S.P.A. Processes for the production of polymorphic forms of rifaximin
ITMI20032144A1 (it) 2003-11-07 2005-05-08 Alfa Wassermann Spa Forme polimorfe di rifaximina, processi per ottenerle e
US7902206B2 (en) 2003-11-07 2011-03-08 Alfa Wassermann, S.P.A. Polymorphic forms α, β and γ of rifaximin
US20080262024A1 (en) * 2003-11-07 2008-10-23 Giuseppe Claudio Viscomi Rifaximin compositions and method of use
US7906542B2 (en) 2004-11-04 2011-03-15 Alfa Wassermann, S.P.A. Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin
US8003118B2 (en) * 2005-03-02 2011-08-23 Kodsi Robert E Use of rifaximin for the prevention of aspiration pneumonia and/or sepsis
US20060210483A1 (en) * 2005-03-02 2006-09-21 Kodsi Robert E Non-systemic antibiotic formulations and related method of use and treatment of upper respiratory infections
US20060210492A1 (en) * 2005-03-02 2006-09-21 Kodsi Robert E Use of rifaximin for treatment and prevention of periodontal conditions
DK1698630T3 (da) * 2005-03-03 2014-12-08 Alfa Wassermann Spa Nye polymorfe former af rifaximin, fremgangsmåde for deres fremstilling og anvendelse deraf i de medicinske præparater
ITBO20050123A1 (it) 2005-03-07 2005-06-06 Alfa Wassermann Spa Formulazioni farmaceutiche gastroresistenti contenenti rifaximina
CN101594885B (zh) 2006-03-09 2017-07-18 萨利克斯药品公司 利福昔明抗直肠功能障碍制剂
PL2054066T3 (pl) 2006-08-02 2015-12-31 Salix Pharmaceuticals Inc Sposoby leczenia popromiennego zapalenia jelit
ITMI20061692A1 (it) 2006-09-05 2008-03-06 Alfa Wassermann Spa Uso di polioli per ottenere forme polimorfe stabili di rifaximina
EP2069363B1 (en) * 2006-09-22 2013-03-20 Cipla Ltd. Rifaximin in an amorphous form
US20080161337A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Chronic Prostatitis
US20080159987A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Restless Legs Syndrome
ITMI20071241A1 (it) * 2007-06-20 2008-12-21 Solmag S P A Processo per la preparazione di rifaximina amorfa e rifaximina amorfa cosi' ottenuta
US7709634B2 (en) 2007-09-20 2010-05-04 Apotex Pharmachem Inc. Amorphous form of rifaximin and processes for its preparation
EP2257557A4 (en) * 2008-02-25 2011-06-29 Salix Pharmaceuticals Ltd FORMS OF RIFAXIMINE AND APPLICATIONS THEREOF
US8486956B2 (en) 2008-02-25 2013-07-16 Salix Pharmaceuticals, Ltd Forms of rifaximin and uses thereof
CN101959412A (zh) 2008-02-26 2011-01-26 萨利克斯药品有限公司 治疗肠病的方法
US11779571B2 (en) 2008-02-26 2023-10-10 Salix Pharmaceuticals, Inc. Methods for treating irritable bowel syndrome (IBS)
PL2294012T3 (pl) 2008-05-07 2014-12-31 Salix Pharmaceuticals Inc Podawanie środka czyszczącego jelito i antybiotyku w leczeniu choroby jelit
CN101585843B (zh) * 2008-05-21 2011-07-06 重庆赛诺生物药业股份有限公司 一种利福昔明的制备工艺
US7928115B2 (en) 2008-10-02 2011-04-19 Salix Pharmaceuticals, Ltd. Methods of treating travelers diarrhea and hepatic encephalopathy
US20110035232A1 (en) 2008-10-02 2011-02-10 Salix Pharmaceuticals, Ltd. Methods of treating hepatic encephalopathy
US12285414B2 (en) 2008-10-02 2025-04-29 Salix Pharmaceuticals, Inc. Methods of treating hepatic encephalopathy
ES2770308T3 (es) 2008-10-02 2020-07-01 Salix Pharmaceuticals Ltd Procedimientos de tratamiento de encefalopatía hepática
ES2718614T3 (es) 2008-12-10 2019-07-03 Cipla Ltd Complejos de rifaximina
IT1397617B1 (it) * 2009-04-20 2013-01-18 Alfa Wassermann Spa Nuovi derivati della rifamicina
NZ596851A (en) 2009-06-02 2013-10-25 Salix Pharmaceuticals Ltd Methods of treating hepatic encephalopathy
BR112012005627A2 (pt) 2009-09-13 2017-02-21 Salix Pharmaceuticals Ltd "uso de rifaximina para preparação de um medicamento para tratar síndrome do intestino irritável (ibs)"
EP2503989A2 (en) 2009-11-23 2012-10-03 Cipla Limited Topical foam composition
EP2401282B2 (en) 2009-12-28 2017-01-04 Silvio Massimo Lavagna Method for the production of amorphous rifaximin
EP3650022A1 (en) 2010-02-18 2020-05-13 Salix Pharmaceuticals, Ltd. Methods for treating rifampin resistant clostridium difficilis infections
IT1398550B1 (it) 2010-03-05 2013-03-01 Alfa Wassermann Spa Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo
CA2802874A1 (en) * 2010-06-16 2011-12-22 Apotex Pharmachem Inc. Polymorphic forms of rifaximin
PT2593463T (pt) 2010-07-12 2020-09-17 Salix Pharmaceuticals Ltd Formulações de rifaximina e usos das mesmas
US8759513B2 (en) 2010-09-13 2014-06-24 Sequent Scientific Limited Polymorphic form of rifaximin and process for its preparation
CA2825964A1 (en) 2011-02-11 2012-08-16 Salix Pharmaceuticals, Ltd. Forms of rifaximin and uses thereof
AU2012251385A1 (en) 2011-05-02 2013-11-21 Ranbaxy Laboratories Limited Rifaximin dimethylformamide solvate
WO2012155981A1 (en) 2011-05-19 2012-11-22 Friulchem Spa New process for the synthesis of rifaximin and a new pseudo-crystalline form of rifaximin obtained thereby
ITBO20110461A1 (it) 2011-07-29 2013-01-30 Alfa Wassermann Spa Composizioni farmaceutiche comprendenti rifaximina, processi per la loro preparazione e loro uso nel trattamento di infezioni vaginali.
PL2773205T3 (pl) 2011-11-02 2024-09-02 Salix Pharmaceuticals, Inc. Ryfaksymina w leczeniu ustępującej biegunki z przewagą zespołu jelita drażliwego
US9359374B2 (en) 2012-06-13 2016-06-07 Apotex Pharmachem Inc. Polymorphic forms of rifaximin
ITBO20120368A1 (it) 2012-07-06 2014-01-07 Alfa Wassermann Spa Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso.
EP2971062A2 (en) 2013-03-15 2016-01-20 ALFA WASSERMANN S.p.A. Method for diagnosing vaginal infections
EA201591267A1 (ru) 2013-03-15 2016-03-31 Альфа Вассерманн С.П.А. Рифаксимин для применения в лечении вагинальных инфекций
AU2014252219B2 (en) 2013-04-12 2018-11-22 Alfasigma S.P.A. NSAID administration and related compositions, methods and systems.
US9018225B1 (en) 2013-07-26 2015-04-28 Novel Laboratories Rifaximin crystalline forms and methods of preparation thereof
ITMI20131307A1 (it) 2013-08-02 2015-02-02 A M S A Anonima Materie Sint & Affini S P A Processo per la preparazione di refaximina k
CN103509038B (zh) * 2013-09-30 2016-01-20 浙江思贤制药有限公司 一种新晶型利福昔明ζ及其制备方法
EP2927235B1 (en) 2014-03-31 2017-02-08 Euticals S.P.A. Polymorphic mixture of rifaximin and its use for the preparation of solid formulations
WO2015171493A1 (en) 2014-05-04 2015-11-12 Salix Pharmaceuticals, Inc. Ibs microbiota and uses thereof
HUE044748T2 (hu) 2014-05-12 2019-11-28 Alfasigma Spa Rifaximin új szolvatált kristályos formája, annak elõállítása, azokat tartalmazó kompozíciók, és alkalmazásuk
EP2982764A1 (en) 2014-08-05 2016-02-10 ALFA WASSERMANN S.p.A. Identification of vaginal bacteria
US9988398B2 (en) 2016-06-07 2018-06-05 Cadila Healthcare Limited Crystalline form of rifaximin and process for its preparation
CN110072525B (zh) 2016-09-30 2022-12-02 萨利克斯药品公司 利福昔明的固态分散形式
RU2020102511A (ru) * 2017-06-26 2021-07-27 Биофер С.П.А. Соединения пиридо-имидазо рифамицина в качестве антибактериального средства

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1154655B (it) * 1980-05-22 1987-01-21 Alfa Farmaceutici Spa Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica

Also Published As

Publication number Publication date
ES8603489A1 (es) 1986-01-01
US4557866A (en) 1985-12-10
JPS60252483A (ja) 1985-12-13
PT80446B (pt) 1987-11-11
FI851907L (fi) 1985-11-16
GR851144B (en]) 1985-11-25
FI851907A0 (fi) 1985-05-14
EP0161534B1 (en) 1989-09-20
AU4251585A (en) 1985-11-21
EP0161534A2 (en) 1985-11-21
IE58392B1 (en) 1993-09-08
DK162647C (da) 1992-04-13
AR241913A1 (es) 1993-01-29
EP0161534A3 (en) 1987-03-04
IT8403463A0 (it) 1984-05-15
CA1215708A (en) 1986-12-23
ATE46512T1 (de) 1989-10-15
DK162647B (da) 1991-11-25
JPH0469634B2 (en]) 1992-11-06
IE851191L (en) 1985-11-15
NO164242B (no) 1990-06-05
NO164242C (no) 1990-09-12
FI81101C (fi) 1990-09-10
ZA852971B (en) 1985-12-24
DE3573120D1 (en) 1989-10-26
DK214685D0 (da) 1985-05-14
AU568934B2 (en) 1988-01-14
PT80446A (en) 1985-06-01
ES543115A0 (es) 1986-01-01
PH22007A (en) 1988-05-02
DK214685A (da) 1985-11-16
NO851921L (no) 1985-11-18
FI81101B (fi) 1990-05-31

Similar Documents

Publication Publication Date Title
IT1199374B (it) Processo per la preparazione di pirido-imidazo-rifamicine
IT8519847A0 (it) Processo per la preparazione di fluorossi-alo-composti.
IT1191632B (it) Processo per la preparazione di (2,2)-paraciolofano
IT1136945B (it) Processo per la preparazione di l-carnitina
IT8423280A1 (it) Processo per la sintesi di 2-metossi-6-bromo-naftalene
IT1177104B (it) Processo per la preparazione di (2,2)-paraciclofano
IT1139269B (it) Processo per la preparazione di 1,1-dialo-1,2,2,2-tetrafluoroetani
IT1199413B (it) Processo per la preparazione di pirido-imidazo-rifamicine
IT1186782B (it) Processo per la preparazione di fenilpropanoni
IT1206727B (it) Processo per la preparazione di carbinoli polialogenati.
IT1186708B (it) Processo per la preparazione di 2-perfluoropropossi-perfluoropropio nilfluoruro
IT8421520A0 (it) Processo per la preparazione dicomposti carbonilici.
BR8506175A (pt) Processo de preparacao de galoborossilicato
IT8620575A1 (it) Processo per la preparazione di eteri alchilterbutilici
IT1175989B (it) Procedimento per la preparazione di polifenileteri
IT8720230A0 (it) Processo per la preparazione di 1-alchil-3-carbossi-4-cinnoloni.
IT1209936B (it) L-serina metodo per la produzione di
IT1173204B (it) Processo per la preparazione di novolacche
IT8403465A0 (it) Processo per la preparazione di imidazo-rifamicine
IT8420174A0 (it) Processo per la preparazione di tiocarbammati.
IT1199375B (it) Processo per la preparazione di imidazo rifamicine
IT1170000B (it) Processo per la preparazione di alchil-naftileteri
IT1164177B (it) Processo per la preparazione di alfa-cheto-acidi
IT1155063B (it) Processo per la preparazione di adrenocromo
IT1139844B (it) Processo per la preparazione di amikacina

Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19940505